PREDICTION OF EJECTION FRACTION OF LEFT VENTRICLE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS ON EMPAGLIFLOZIN: A SIX-MONTH ASSESSMENT
Keywords:
diabetes mellitus, machine learning, risk prediction, EMPAGLIFLOZINAbstract
Diabetes mellitus type 2 (T2DM) is a growing global health concern, often leading to cardiovascular complications, including left ventricular dysfunction. Predicting left ventricular ejection fraction (LVEF) can be crucial for early intervention and management. Empagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor, has garnered attention for its efficacy in managing type 2 diabetes mellitus (T2DM) and its potential cardiovascular benefits. This study aims to identify significant predictors of LVEF in T2DM patients treated with Empagliflozin after six months of therapy. We aim to identify outcomes related to cardiac function and the predictive factors influencing LVEF changes during this treatment phase. We applied a systematic feature selection approach through generalized linear models (GLM) to build a predictive model based on a cohort of 130 patients.
References
American Diabetes Association (2020). 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2020. Diabetes care, 43(Suppl 1), S14–S31. https://doi.org/10.2337/dc20-S002
Verma, S., Dhingra, N. K., Butler, J., Anker, S. D., Ferreira, J. P., Filippatos, G., Januzzi, J. L., Lam, C. S. P., Sattar, N., Peil, B., Nordaby, M., Brueckmann, M., Pocock, S. J., Zannad, F., Packer, M., & EMPEROR-Reduced trial committees and investigators (2022). Empagliflozin in the treatment of heart failure with reduced ejection fraction in addition to background therapies and therapeutic combinations (EMPEROR-Reduced): a post-hoc analysis of a randomised, double-blind trial. The lancet. Diabetes & endocrinology, 10(1), 35–45. https://doi.org/10.1016/S2213-8587(21)00292-8
Liu, D., Hu, K., Schregelmann, L., Hammel, C., Lengenfelder, B. D., Ertl, G., Frantz, S., & Nordbeck, P. (2023). Determinants of ejection fraction improvement in heart failure patients with reduced ejection fraction. ESC heart failure, 10(2), 1358–1371. https://doi.org/10.1002/ehf2.14303.
Ikramov, A., Mukhtarova, S., Trigulova, R., et al. Prediction of glycosylated hemoglobin level in patients with cardiovascular diseases and type 2 diabetes mellitus with respect to anti-diabetic medication. Front. Endocrinol. 15:1305640 (2024). doi:10.3389/fendo.2024.1305640
Trigulova, R.Kh., Mukhtarova, Sh.Sh., Alimova, D.A., et al. Features of the Trajectories of Glycated Hemoglobin in Patients with CHD and DM 2. American Heart Journal, Volume 267, 2024, Page 121, ISSN 0002-8703, https://doi.org/10.1016/j.ahj.2023.08.024
Alimova, D., Ikramov, A., Trigulova, R., et al. Prediction of Diastolic Dysfunction in Patients with Cardiovascular Diseases and Type 2 Diabetes with Respect to Covid-19 in Anamnesis Using Artificial Intelligence. In Proceedings of the 2023 7th International Conference on Medical and Health Informatics (ICMHI '23). Association for Computing Machinery, pp. 61–65 (2023). https://doi.org/10.1145/3608298.3608310